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Amongst aquatic microorganisms, cyanobacteria occupy an important place on Earth because of their historical and ongoing global importance in ecosystem functioning. Moreover, in the present many serve as the threats that can generate toxins, especially in inland water bodies. Peri-alpine lakes are still the place where some blooming species (e.g. Planktothrix) regularly occur. Our work contribute to analyse abiotic and biotic interactions with cyanobacteria and address the determinism, toxin risk and management dealing with harmful cyanobacterial blooms with the idea to develop predictive models